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cisplatin 2

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HM781-36B 1

epidermal growth factor receptor 1

hepatocellular carcinoma 1

molecular targeted therapy 1

nasopharyngeal carcinoma 1

reactive oxygen species 1

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A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 275-289 doi: 10.1007/s11684-022-0945-y

Abstract: explored the anti-tumor effects of the novel pan-HER inhibitor HM781-36B, alone or in combination with cisplatinHM781-36B exerted synergistic effects with cisplatin on inhibiting proliferation and promoting apoptosisIn NPC xenograft models in nude mice, HM781-36B and cisplatin synergistically inhibited tumor growth.and regulating tumor microenvironment may explain the synergistic anti-tumor effects of HM781-36B and cisplatinThe pan-HER inhibitor HM781-36B alone or in combination with cisplatin represents promising therapeutic

Keywords： growth factor receptor     ErbB receptors     HM781-36B     nasopharyngeal carcinoma     molecular targeted therapy     cisplatin    

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Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 227-235 doi: 10.1007/s11684-014-0327-1

Abstract: The platinum-based chemotherapeutic agent cisplatin displays a wide range of antitumor activities.However, the molecular mechanism of cisplatin-induced accelerated senescence in hepatocellular carcinomaIn the present study, the growth inhibitory effect of cisplatin on HepG2 and SMMC-7721 cells was detectedOur results revealed that cisplatin reduced the proliferation of HepG2 and SMMC-7721 cells in a dose-Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation.

Keywords： reactive oxygen species     senescence     cisplatin     hepatocellular carcinoma    

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Inhibitory activity of Bifidobacterium adolescent combined with cisplatin on melanoma in mice and its

HUANG Hongying, LIU Guangchao, QI Yijun, DU Yaowu, CHEN Jugao, MA Yuanfang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 186-190 doi: 10.1007/s11684-008-0035-9

Abstract: The aim of this study is to explore inhibitory activity of Bifidobacterium adolescent combined with cisplatincells to construct mouse model of melanoma and treated with bifidobacterium adolescent combined with cisplatinThe B16 cell proliferation was arrested at S stage after treatment with cisplatin.Treatment with bifidobacterium combined with cisplatin can enhance the inhibitory activity on the growthof melanoma (B16) of cisplatin.
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Title Author Date Type Operation

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal

Journal Article

Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Journal Article

Inhibitory activity of Bifidobacterium adolescent combined with cisplatin on melanoma in mice and its

HUANG Hongying, LIU Guangchao, QI Yijun, DU Yaowu, CHEN Jugao, MA Yuanfang

Journal Article